Cannabidiol (CBD) as a Promising Anti-Cancer Drug


Cannabidiol (CBD) as a Promising Anti-Cancer Drug

Cannabidiol (CBD) as a Promising Anti-Cancer Drug

1 Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568, USA
2 Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
* Author to whom correspondence should be addressed.
These authors contributed to this paper equally.
Cancers 202012(11), 3203;
Received: 12 August 2020 / Revised: 15 October 2020 / Accepted: 27 October 2020 / Published: 30 October 2020
(This article belongs to the Collection Drug Resistance and Novel Therapies in Cancers)
The use of cannabinoids containing plant extracts as herbal medicine can be traced back to as early as 500 BC. In recent years, the medical and health-related applications of one of the non-psychotic cannabinoids, cannabidiol or CBD, has garnered tremendous attention. In this review, we will discuss the most recent findings that strongly support the further development of CBD as a promising anti-cancer drug.
Recently, cannabinoids, such as cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a wide array of organic molecules, including those that are physiologically produced in humans, synthesized in laboratories, and extracted primarily from the Cannabis sativa plant. These organic molecules share similarities in their chemical structures as well as in their protein binding profiles. However, pronounced differences do exist in their mechanisms of action and clinical applications, which will be briefly compared and contrasted in this review. The mechanism of action of CBD and its potential applications in cancer therapy will be the major focus of this review article. View Full-Text

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MDPI and ACS Style

Seltzer, E.S.; Watters, A.K.; MacKenzie, D., Jr.; Granat, L.M.; Zhang, D. Cannabidiol (CBD) as a Promising Anti-Cancer Drug. Cancers 202012, 3203.

Article Source : MDPI