02 Nov CBD Reduces Cocaine Addiction and Withdrawal
New Research Shows CBD Reduces Cocaine Addiction and Withdrawal
New Research Shows CBD Reduces Cocaine Addiction and Withdrawal.
Science Direct published an abstract by Western Sydney Australia’s University School of Medicine only days ago that showed the results of five individual experiments. The researchers concluded that administration of 10mg per KG drastically reduced the preference for the drug over cannabidiol in only 20 days which is very promising. Their research was extensive but their publishing scant to date – in multiple studies they were able to prove that cannabidiol reduced the urge so much that it was beyond apparent within only one day after cessation of the hemp constituent as patients would immediately gain cravings upon stopping the CBD.
Many have debated the efficacy of CBD in the treatment of addictions and with good merit as with the opioid crisis there’s been an upswing of THC use as well as other cannabinoids to control pain with CBD not always taking the drivers seat. But, when it comes to the reduction of Post Acute Withdrawal Syndrome (PAWS) there’s been multitudes of study and patient testimony to clearly indicate Hemp extracts – including CBD – play a very vital role as they are less likely to cause lightheadedness, anxiety, or depress the Central Nervous System which can increase depressive states that come with post acute withdrawal.
Much like other research in relation to Cannabidiol’s promising future in the treatment of addiction it’s coupled with anecdotal tales of today that verify through patients that research like this is on target.
Here’s what they published:
Received 12 August 2020, Revised 26 October 2020, Accepted 26 October 2020, Available online 27 October 2020.
Cocaine addiction is a global health problem with no approved pharmacotherapies. Preclinical research indicates the non-intoxicating phytocannabinoid, cannabidiol (CBD), can reduce addiction-relevant behaviour for several drug classes (e.g. ethanol, opiates, psychostimulants) in rodents. However, research into the effects of CBD on cocaine addiction-like behaviours is limited, and the acute effects of CBD on cocaine reward are unknown.
The present experiments sought to clarify the effects of CBD (10 mg/kg) on the acquisition, consolidation, reconsolidation, extinction and drug-primed reinstatement of cocaine (15 mg/kg) conditioned place preference (CPP) in adult male C57BL6/J mice.
In five separate experiments, CBD was administered 1) prior to cocaine-context pairings, to target acquisition of cocaine-context memory; 2) immediately after cocaine-context pairings, to target consolidation of cocaine-context memory; 3) after a brief reactivation session, to target reconsolidation of cocaine memory; 4) prior to extinction sessions; and 5) prior to cocaine-primed reinstatement.
CBD treatment reduced preference for the cocaine-context 20 days after CBD cessation. CBD also reduced consolidation of cocaine memory, and this was evident 1 day after cessation of CBD treatment. Interestingly, CBD treatment also modified cocaine-induced locomotion. CBD did not affect reconsolidation of cocaine-induced place preference, the rate of extinction of cocaine memory, or drug-primed reinstatement of cocaine CPP.
These findings indicate specific effects of acute 10 mg/kg CBD on cocaine memory processes, suggesting delayed effects on cocaine preference and consolidation of cocaine memory, and support the therapeutic utility of CBD for targeting some drug-associated memory processes.
source : global cannabinoid rc